基于TCMSP数据库中药成分的新型冠状病毒3CL水解酶抑制剂虚拟筛选

目的运用分子对接技术模拟预测TCMSP数据库中药成分对新型冠状病毒(SARS-Co V-2)3CL水解酶的作用。方法基于SARS-Co V-2 3CL水解酶的PDB晶型结构(6LU7),构建虚拟靶标模型,以TCMSP数据库中的13 143个化合物为配体筛选对象,以6LU7原配体分子为对照,采用薛定谔2018软件,以Glide程序建立6LU7分子对接体系。然后以原配体分子的对接打分结果为阈值,口服生物利用度(OB)≥30%或类药性(DL)≥0.18为标准筛选候选化合物。最后建立"成分-药材-归经-功效"网络,对候选成分的主要药材归属和作用功效进行总结。结果按照对接打分、OB、DL筛选标准,共筛选得到60个化合物。受体-配体相互作用结果显示,候选化合物主要与靶点蛋白的GLU166、GLY143、ASP187、CYS145、GLN189和LEU141等发生氢键作用。网络预测结果显示,所筛选化合物主要归属药材为甘草、桑白皮、满山红、虎杖和车前草等,肺脏是作用的关键靶器官,其作用功效以清热解毒、止咳祛痰、泻肺平喘等为主。结论对TCMSP数据库化合物进行虚拟分子对接得到的结果为SARS-CoV-2 3CL水解酶抑制剂筛选提供了相关数据。     

微信式医院家庭协作延续护理在直肠癌结肠造口患者中的应用

目的 探索基于微信的医院家庭协作延续护理在直肠癌肠造口患者中的应用效果.方法 将80名直肠癌肠造口患者随机分入两组,观察组给以基于微信的医院家庭协作延续护理,对照组实行常规护理模式.对比两组患者护理前后自护能力,生活质量以及并发症发生情况.结果 护理后,观察组自护能力评分明显优于对照组(P<0.05);护理后两组生活质量评分明显提高,且观察组高于对照组(P<0.05).观察组和对照组并发症发生率分别为7.50%和37.50%,显示差异具有统计学意义(P<0.05).结论 基于微信的医院家庭协作延续护理可有效提高直肠癌肠造口患者自护能力,改善生活质量,减少并发症.     

医院物业持续改进工作平台建设

医院物业与医院的日常运行关系密切相关,医院物业管理的水平和效率直接影响到医院工作的方方面面。为提升医院整体管理的水平,从医院物业的特点出发,认真分析物业工作现状,根据持续改进医疗服务工作的需要,引入闭环管理思维,打造医院物业持续改进工作平台,使得医院物业管理工作在物业质量、生产安全、人性化服务上取得了长足的进步,医院物业管理水平得到了全面的提升。     

Public Awareness and Mask Usage during the COVID-19 Epidemic: A Survey by China CDC New Media

An online survey conducted March 18–19, 2020 on the official China CDC WeChat account platform was used to evaluate the effect of public education about masks usage during the new coronavirus disease 2019 (COVID-19) epidemic. Chinese nationals older than 18 were eligible for the survey. The survey collected 5,761 questionnaires from the 31 provinces, municipalities, and autonomous regions of mainland China. 99.7% and 97.2% of the respondents answered correctly that respiratory droplets and direct contact were the main transmission routes. 73.3% of the respondents considered COVID-19 to be ‘serious’ or ‘very serious’. When going to the hospital, 96.9% (2,885/2,976 had gone to a hospital) used a mask during the COVID-19 epidemic, while 41.1% (2,367/5,761) did not use a mask before the epidemic. Among the respondents that used public transportation and went shopping, 99.6% and 99.4%, respectively, wore masks. Among respondents who returned to work, 75.5% wore a mask at the workplace, while 86.3% of those who have not returned to work will choose to use masks when they return to the workplace. The Chinese public is highly likely to use a mask during COVID-19 epidemic, and the mask usage changed greatly since the COVID-19 outbreak. Therefore, public education has played an important role during the COVID-19 epidemic.     

Platform switching minimises crestal bone loss around dental implants: truth or myth?

The aim was to assess the role of platform switching (PS) in minimising crestal bone loss around dental implants through a systematic review of the currently available clinical evidence. To address the focused question ‘Does PS minimise crestal bone loss compared with non‐platform‐switched (NPS) implants?’, PubMed/Medline and Google Scholar databases were explored from 1986 up to and including December 2013 using the following key words in different combinations: ‘bone loss’, ‘dental implant’, ‘diameter’, ‘mandible’, ‘maxilla’ and ‘platform switching’. Letters to the Editor, unpublished data, historical reviews, case reports and articles published in languages other than English were excluded. Fifteen clinical studies were included. In seven studies, PS and NPS implants were placed in both the maxilla and mandible. In 13 studies, implants were placed at crestal bone levels whereas in one study, implants were placed supracrestally. Three studies reported the bucco‐lingual (or transversal) width of the alveolar ridge which ranged between 7–8 mm. Seven studies reported that implants placed according to the PS concept did not minimise crestal bone loss as compared with NPS implants. 3D‐Implant positioning, width of alveolar ridge and control of micromotion at the implant‐abutment interface are the more critical factors that influence crestal bone levels than PS.     

Unique approach to sensorimotor training with a new device combining air cushion with stochastic translations—A prospective randomized controlled clinical trial

Sensorimotor training with a wide variety of available devices represents an important component in rehabilitation and prevention of different sports injuries and chronic diseases. The purpose of this study was to evaluate the effects of a sensorimotor training with a newly developed device, which consists of an instable platform moving on an air cushion, providing dynamic balance training by tilting and unanticipated stochastic translations on postural control. Seventy-two healthy young subjects were included in this prospective, randomized, controlled, and observer-blinded study. Balance was objectively assessed by posturography and Functional Reach Test (FRT). Additionally we evaluated the subjective rating of balance. After randomization the sensorimotor training group performed a training program on the new device over a 5–6 week study period. After this time improvement in objective and subjective measurements as a result of training became evident. A significant difference in challenging posturographic parameters (Sensory Organization Test 5: training group 5.32 ± 5.25 vs. control group 1.78 ± 5.05, p = 0.006 and Head Shake Sensory Organization Test 5: training group 11.94 ± 8.97 vs. control group 5.41 ± 10.17, p = 0.01) as well as a significant difference in the FRT (training group 3.34 ± 3.35 cm vs. control group 0.01 ± 2.97 cm, p = 0.0001) was found. Subjective assessment revealed a significant improvement in the participants’ rating of balance and alteration of balance. Subjects showed a high satisfaction with the new training device. Our findings suggest that the newly developed device could be a promising option for sensorimotor training to improve postural control.